中文摘要：

目的观察T细胞缺陷对日本血吸虫感染宿主存活时间，肝脏虫卵肉芽肿形成及日本血吸虫雌虫产卵的影响。方法T细胞缺陷小鼠（裸鼠）和BALB／c小鼠各20只，每只感染日本血吸虫尾蚴（25±1）条，记录感染后存活时间。感染后第42d，从2组存活小鼠中各随机取7只剖杀，取肝组织，计数肝内虫卵；制作肝组织切片，观察虫卵肉芽肿病理学变化，并测量单个虫卵肉芽肿直径。结果20只裸鼠感染日本血吸虫后46d全部死亡。裸鼠肝组织中的雌虫产卵数为（4759．5±2161．3）个／条，BALB／c小鼠为（7323．4±2254．6）个／条，差异有统计学意义（P％0．05）。裸鼠肝脏中单个虫卵肉芽肿直径为（138．4±31．9）μm，与感染组BALB／c小鼠（316．4±68．2）μm比较，差异有统计学意义（P〈0．01），且不能形成典型局限性虫卵肉芽肿，肉芽肿内嗜酸性粒细胞明显减少，周围肝组织伴有大面积坏死。结论宿主T细胞对虫卵肉芽肿的形成和维持感染宿主的生存具有重要作用。

英文摘要：

Objective To observe host survival time and egg granuloma formation in the liver of T-cell deprived mice in- fected with Schistosoma japonicum. Methods Twenty T-cell deprived mice （nu/nu） and 20 BALB/c mice were used. Mice in both groups were infected with 25＋_ 1 S. japonicum cercariae and their survival time after the challenge was re- corded. Seven mice in each group were randomly selected and sacrificed on day 42 after the challenge to count the eggs in the liver and to histologically examine single egg granulomas in the liver and determine their size. Results The survival time of all 20 nude mice after infection was no more than 46 days. The number of eggs per pair of worms in the liver of nude mice was significantly lower （4 759.5±2 161. 3） than that in BALB/c mice（7 323.4 ± 2254. 6）（P〈0.05）. Egg granulomas in the livers of nude mice were ill-defined. Single egg granulomas in the liver of nude mice were significantly smaller（138. 4±31.9） μm than those in BALB/c mice （316.4±68. 2） μm （P〈0. 01）. A significant and selective de- crease in the number of eosinophils within the granulomas was noted in nude mice in comparison to BALB/c mice. In addi- tion, hepatocyte necrosis in the vicinity of eggs was obvious in nude mice. Conclusion T cells play an important role in egg granuloma formation and prolong the survival of mice infected with S. japonicum.