中文摘要：

SUMO化作为一种重要的蛋白质翻译后修饰方式,其为人们熟知的功能是调控转录蛋白的细胞核内外定位与基因转录调节活性。近年来,研究发现SUMO/去SUMO化修饰的底物不仅限于核内与核周蛋白,一些膜蛋白,如钾离子通道、谷氨酸盐和红藻氨酸盐受体亚基、TGF-β受体等,均可作为SUMO/去SUMO化修饰的底物。本文就SUMO/去SUMO化修饰在膜蛋白功能调控这一新兴领域的最新进展作一介绍。

英文摘要：

As a type of important protein post-translational modification,the well-known role of sumoylation is to mediate import/export and activition of transcription-related proteins.In recent years,it was reported that the substrates modified by sumoylation extend to several membrane proteins,such as potassium ion channel,glutamate and kainate receptor subunit,and TGF-βreceptor,in additional to nuclear and perinuclear proteins.This review briefly introduces the advances about this newly emerging field of membrane protein function regulated by sumoylation.