中文摘要：

目的：探讨孟鲁司特钠联合抗生素对哮喘患儿T淋巴细胞亚群CD4＋和CD8＋水平的影响。方法：选取我院收治的哮喘患儿50例,并将其随机分为两组,每组各25例。对照组予常规抗生素治疗,实验组在此基础上加用孟鲁司特钠治疗。观察和比较两组患儿的临床疗效、一年内复发率,以及CD4＋、CD8＋和CD4＋/CD8＋比值的变化情况。结果：两组哮鸣音、咳嗽及喘憋持续时间均获得改善,实验组优于对照组,差异有统计学意义（P〈0.05）。与同组治疗1天后比较,两组患儿治疗5、10天后的CD4＋、CD8＋以及CD4＋/CD8＋比值均明显升高;与同组治疗5天后比较,两组患儿治疗10天后CD4＋、CD8＋以及CD4＋/CD8＋比值均明显升高;实验组患儿治疗5天、10天后的CD4＋、CD8＋以及CD4＋/CD8＋比值均明显高于对照组,差异均有统计学意义（P〈0.05）。两组治疗后CD4＋、CD8＋以及CD4＋/CD8＋比值变化呈显著差异（P〈0.05）。实验组1年复发率显著低于对照组,差异有统计学意义（P〈0.05）。结论：孟鲁司特钠可能通过影响哮喘患儿CD4＋、CD8＋及CD4＋/CD8＋水平,改善患儿的临床症状,缩短其住院时间,值得临床推广应用。

英文摘要：

Objective： To investigate the effect of montelukast sodium combined with antibiotics on the T lymphocyte subsets CD4＋ and CD8~ levels of asthmatic children. Methods： 50 children with asthma admitted in our hospital were selected and randomly divided into two groups with 25 cases in each group. The control group was treated with conventional antibiotics, while the experimental group was treated with the reduning on the basis of the control group. Then the clinical efficacy, recurrence rate within 1 year, and the changes of CD8＋, CD4＋ levels as well as ratio of CD4＋/CD8＋ were compared between two groups. Results： Wheeze, cough and asthma duration were improved, in both groups and the experimental group was better than the control group （P〈0.05）. The CD4＋, CD8＋ levels and CD4＋/CD8＋ ratio were significantly increased after 5, 10 days＇ treatmentcompared with those on the 1st day of treatment. The CD4＋, CD8＋ levels and CD4＋/CD8＋ ratio were significantly increased after 10 days＇ treatment compared with those after 5 days＇ treatment. The CD4＋, CD8＋ levels and CD4＋/CD8＋ ratio of experimental group were significantly higher than those of the control group after 5 days＇ and 10 days＇ treatment （P〈0.05）. Significant differences were found in CD4＋, CD8＋ levels and CD4＋/CD8＋ ratio between the two groups after treatment （P〈0.05）. The 1 year recurrence rate of experiment group was significantly lower than that of the control group （P〈0.05）. Conclusions： Montelukast could improve the CD4＋ and CD8＋levels, restore the immune system fimction and promote the clinical effect of children with asthma.