核酸适配体(aptamer)是一类由指数富集配体系统进化(systematic evolution of ligands by exponential enrichment, SELEX)技术筛选出的RNA和单链DNA寡核苷酸片段。因其非同寻常的分子识别能力及结构特性,核酸适配体已经成为最具有应用前景的生物分子之一,综述了核酸适配体结合不同的纳米材料在肿瘤靶向治疗上的应用。
Aptamers is a kind of oligonucleotides which are isolated through a process termed systematic evolution of ligands by exponential enrichment. Because of its peculiar molecular recognition ability and the specific structure, aptamer is one of the most prospectly biological molecules. An overview of recent developments in aptamer nanomaterial hybrid was presented.