This study aims to quantify the impact of typhoon ‘Koppu’ on infectious diarrhea in Guangdong, China in 2009. Rate ratios (RRs) were calculated by comparing person-time of infectious diarrhea cases between typhoon period and reference period. RRs of dysentery and other infectious diarrhea increased to a maximum of 1.12 (95% CI, 0.86-1.47), 1.10 (95% CI, 1.00-1.20) on the fifth lag day respectively. Children under 5 years were more vulnerable to infectious diarrhea, especially to other infectious diarrhea [RR: 1.21 (1.07-1.36) Vs. 1.03 (0.89-1.82)] after typhoon compared with people aged 〉5 years when RRs were at maximum. A mildly increased risk of infectious diarrhea was not only observed in great damaged regions, but also in other areas.