中文摘要：

目的探讨新疆哈萨克族原发性高血压患者外周血单核细胞Toll样受体4（TLR4）表达及与血脂、血糖、肥胖的相关性。方法根据高血压诊断标准,选取68例新疆哈萨克族原发性高血压患者为高血压组,70例哈萨克族健康人为对照组,测量血压（BP）、身高、体质量、腰围（WC）、臀围（HC）,抽取空腹静脉血测定血糖（FPG）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）水平及白细胞计数（WBC）和单核细胞计数（MC）。采用流式细胞仪检查外周血单核细胞上TLR4表达。计算体质指数（BMI）、腰臀比（WHR）。结果高血压组血浆TLR4阳性率高于对照组,差异有统计学意义（P〈0.05）;两组BMI、WC、SBP、DBP、TC、LDL-C、WBC、MC比较,差异均有统计学意义（P〈0.05）;两组WHR、FPG、TG、HDL-C水平比较,差异均无统计学意义（P〉0.05）。相关分析和多元逐步回归分析结果显示,外周血单核细胞TLR4阳性率与LDL-C、TC呈正相关（P〈0.01）;LDL和TC进入多元线性回归方程,是影响TLR4的危险因素。结论哈萨克族原发性高血压患者外周血TLR4阳性率增高,TLR4阳性率与与血脂水平存在相关性。

英文摘要：

Objective To explore the expression of Toll-like receptor 4（TLR4） in peripheral blood mononuclear cell（PBMC） and its relationship to blood lipid,blood glucose and obesity in patients with essential hypertension（EH） of Xinjiang Kazakh. Methods According to diagnostic criteria of hypertension,68 Kazakh EH patients were enrolled as EH group,70 healthy subjects as control.BP,height,weight,waist circumference（WC）,hip circumference（HC） were measured,and fasting venous blood drawn to determine levels of fasting plasma glucose（FPG）,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C） and white blood cell（WBC） count and monocyte count（MC）.Flow cytometer was used to detect PBMC TLR4 expression.Body mass index（BMI） and waist to hip ratio（WHR） was calculated. Results Positive rate of plasma TLR4 was significantly higher in EH group than in control（P0.05）;there was difference in BMI,WC,SBP,DBP,TC,LDL-C,WBC,MC between 2 groups（P0.05）,but not in WHR,FPG,TG,HDL-C（P0.05）.The results of correlation analysis and multiple regression analysis showed that the positive rate of PBMC TLR4 was positively related to LDL-C,TC（P0.01）.LDL-C and TC were risk factors influencing TLR4. Conclusion In EH patients in Xinjiang Kazakh,the positive rate of PBMC TLR4 increases,which is correlated with blood lipid.