中文摘要：

胚胎时期的发育状况与成年人2型糖尿病的发生密切相关.胰十二指肠同源盒（pancreatic and duodenal homeobox 1,PDX1）表达于β细胞发育的所有阶段和成熟的β细胞中,是对整个胰腺形成特别是胎儿期β细胞发育和功能起主要作用的转录因子,同时也是维持成熟β细胞功能所必需的;而pdx1表观遗传修饰的改变会影响其表达,进而影响胰腺发育和β细胞功能.

英文摘要：

The development of embryo has close relation with the occurrence of type 2 diabetes in adulthood and is attracting increasingly more attention recently. Pancreatic and duodenal homeobox 1 （ pdx1 ）expresses in all stages of β-cell development and in mature β cells. As a transcription factor,pdx1 plays a critical role in the formation of whole pancreas,especially in the development and function of β-cell in fetal period,and it is also necessary for the maintenance of mature β-cell function. However, changes in epigenetic modification can alter the expression of pdx1, and then influence pancreatic development and β-cell function . We will make a summary about pdx1 gene structure, function, regulation ,epigenetic modification and so on.