中文摘要：

以（R）-叔丁基亚磺酰胺为手性助剂,与1,3-苯二甲醛经缩合反应制得关键中间体——（Rs,Rs）-双叔丁基亚磺酰亚胺（7）;锂化的羧酸酯与7经不对称加成反应合成了两个新型的Rh2（esp）2配体类似物——（Rs,Rs＇,R,R＇）-β-胺基羧酸酯和（Rs,Rs＇,R,R＇,R,R＇）-α,β-氮杂环丙烷羧酸酯,产率分别为96%和65%,非对映选择性均大于20∶1。化合物的结构经1H NMR和13C NMR表征。

英文摘要：

A synthetic approach toward the enantioenriched analogues of α,α,α＇,α＇-tetramethyl-1,3-benzenedipropionic acid which was the ligand of Rh2（ esp）2catalyst was reported. In this process,the chiral（ R）-tert-butanesulfinyl diimine derived from 1,3-benzenedialdehyde was used in the nucleophilic additions of lithium ester enolates to give two novel chiral analogues of the ＂esp＂esters that are（ Rs,Rs＇,R,R＇）-β-amino esters and（ Rs,Rs＇,R,R＇,R,R＇）-α,β- aziridinyl esters in yields of 96%and 65% with excellent diastereoselectivity（ dr 20 ∶ 1）. The structures were characterized by1 H NMR and13 C NMR.