中文摘要：

左旋多巴被认为是治疗帕金森病的金标准，本文综述了多个相关基因的遗传多态性对左旋多巴药代动力学、药效学及不良反应的影响，以期为指导左旋多巴的临床个体化用药提供基础。

英文摘要：

Levodopa is considered to be the gold standard treatment for Parkinson＇s disease. This review aimed to summarize the influence of genetic polymorphisms on levodopa pharmacoki- netics, pharmacodynamics and adverse reac-tions. In order to provide the basis for guide the clinical individualized medication of levodopa .