中文摘要：

目的探讨云南省不明原因心源性猝死病区人群体内谷胱甘肽过氧化物酶（GSH—Px）活力与心肌损伤的特异性标志物心肌肌钙蛋白Ⅰ（cTnⅠ）的相关性。方法根据是否采取补硒措施将发病地区分为硒干预病区和未干预病区，并在病区外设立对照组。采用5，5’-二硫双-2-硝基苯甲酸（DTNB）分光光度法检测全血GSH-Px活力；酶联免疫吸附试验（EuSA）测定血浆中的cTnⅠ。结果硒干预病区人群GSH-Px活力[（117．913±18．355）U／L]明显高于未干预病区[（96．255±17．358）U／L]及对照组[（100．108±10．091）U／L]，差异有统计学意义（P〈0．05）；未干预病区人群cTnI[（3．2364-0．998）μg／L]最高，对照组[（2．814±0．670）μg／L]次之，硒干预病区[（2．147±0．476）μg／L]最低；GSH—Px活力与cTnI呈显著负相关（r=-0．351，P〈0．01）。结论云南省不明原因心源性猝死病区人群体内GSH—Px活力与cTnI呈负相关，提示提高机体GSH—Px活力水平对心肌损伤可能有保护作用。

英文摘要：

Objective To explore the correlation between blood Glutathione peroxidase activities （GSH- Px） and plasma cardiac troponin I（cTnI） of the people in Yunnan unkown-cause sudden cardiac death areas. Methods The disease areas were divided into two groups, either with selenium supplementor not. The control group was set up in non-disease area. Blood GSH-Px activity was determined with 5,5＇-dithiobis-2-nitrobenzoic acid （DTNB）, and plasma cTnI level was measured with enzyme linked immunosorbent assay （ELISA）. Results Blood GSH-Px activity of selenium-intervened group [ （117.913 ±_ 18.355）U/L ] was higher than those unintervened [（96.255 ± 17.358）U/L] and control group [（100.108 ± 10.091）U/L, P 〈 0.05]. cTnI content of seleniumintervened group[ （2.147 ± 0.476）μg/L] was the lowest among the three groups and the cTnI content of the unintervend group[ （3.236 ±_ 0.998）μg/L] was the highest among the three groups. Plasma cTnI levels were inversely correlated with blood GSH-Px activities（r = - 0.351, P 〈 0.01 ）, the correlation determinant being 0.1232. Conclusions The negative correlation between plasma cTnI and blood GSH-Px activity of the people in Yunnan Unkown-cause Sudden Cardiac Death areas suggesting that the increasing GSH-Px activity resulting from selenium supplementation protects myocardium from damaging.