目的 探讨肠道病毒感染与云南省不明原因心源性猝死的关系。方法 根据流行病学现场调查和临床检查资料在病区设立病例组和病区对照组,在非病区设立非病区对照组,采用巢式反转录聚合酶链反应检测观察对象静脉血中肠道病毒核糖核酸(RNA)。结果 肠道病毒RNA阳性率,病区[56.3%(58/103)]与非病区[41.7%(10/24)]相比有增高趋势,但二者之间差异无统计学意义(χ^2=1.68,P〉0.05);病例组、病区对照组、非病区对照组肠道病毒RNA阳性率分别为56.0%(14/25)、56.4%(44/78)、41.7%(10/24),组间比较差异无统计学意义(χ^2=1.68,P〉0.05),但是各组感染率水平均较高。结论 云南省不明原因心源性猝死病区肠道病毒感染水平较高,两者之间的关系需进一步研究。
Objective To explore the relationship between enterovirus infection and Yunnan endemic sudden cardiac death (YESCD). Methods With the data of field epidemiological study and clinical examination of three groups of YESCD, controls in disease area and controls in non-disease, the ribonucleic acid (RNA) of enterovirus was assayed with reverse transcription nested polymerase chain reaction. Results The positive rates of enterovirus RNA in disease area (56.3%,58/103) was higher than that of controls in non-disease area's(41.7%, 10/24), but it was not significant (χ^2 = 1.68,P 〉 0.05). The positive rates of enterovirus infection increased, although not significantly different among the cases of YESCD (56.0%, 14/25), the controls(56.4% ,44/78) in disease area, and controls(41.7%, 10/24) in non-disease area(χ^2 = 1.68,P 〉 0.05). Conclusions The rates of enterovirus infection was high. The relationship between enterovirus infection and YESCD needs further study.