中文摘要：

N-甲基-D-天门冬氨酸（N-methyl-D-aspartate，NMDA）受体是谷氨酸离子型受体（iGluRs）的一个亚型，由NR1、NR2（A、B、C和D）和 NR3（A、B）7种亚单位组成。NMDA受体的多种亚型与神经病理性疼痛有密切的关系，目前研究与开发的重点是如何应用针对 NMDA受体不同亚型的拮抗剂来治疗神经病理性疼痛。

英文摘要：

N-methyl-D-aspartate（NMDA）receptor is a subtype of ionotropic glutamate recep-tors（iGluRs）.NMDA receptor consists of 7 subunits,NR1,NR2（A,B,C,D）and NR3（A,B）.Re-cent studies have found that there is a close relationship between NMDA receptor subtypes and neuropathic pain.The research and development of peptide antagonists that target NMDA recep-tor subtypes are the focus of the treatment of neuropathic pain.