目的:分析北京协和医院30年间有不孕症的住院患者的子宫内膜异位症(内异症)的患病情况。方法从北京协和医院住院数据库系统检索1983年5月至2013年11月入院的有不孕症的女性患者,筛选出接受了开腹或腹腔镜妇科手术的病例,总结患者的出院诊断及手术名称,记录内异症、盆腔粘连、子宫肌瘤、输卵管积水、卵巢良性肿瘤(非内异症)、子宫肌腺病的发生情况;收集患者的年龄,分析年龄的变化;比较各年内异症例数的变化。结果共有8857例患者满足本研究的分析要求,其中内异症的发生率为35.50%(95%CI为34.50%~36.49%);2004年之前内异症发生率不规则波动,2005年开始较稳定地上升;2005年至2013年内异症的发生率比较,差异有统计学意义(P〈0.01)。1996年起,接受妇科手术的不孕症患者的平均年龄上升,总体差异显著(P〈0.01);1996年的平均年龄为(29.76±3.74)岁,2013年的平均年龄为(32.85±4.49)岁,两者比较,差异有统计学意义(P〈0.01)。诊断为内异症的接受妇科手术的不孕症患者年龄较无内异症者大,分别为(32.67±4.06)、(32.04±4.55)岁,两者比较,差异有统计学意义(P〈0.01);不同年龄组的内异症发生率不同,高年龄组内异症发生率较高(χ2=85.807,P〈0.01)。结论不孕症住院患者中内异症的发生率为35.50%,近年内异症的发生率上升。不孕症患者年龄越大,患内异症的风险可能越高。
Objective To analyze the incidence of endometriosis in inpatients with infertility in Peking Union Medical College Hospital in 30 years. Methods The inpatients of Peking Union Medical College Hospital admitted between May 1983 and November 2013 was searched. The infertile patients receiving laparoscopy or laparotomy were included. The discharge diagnosis and the operation were summarized. The incidence of gynecologic diseases were demonstrated, such as endometriosis, pelvic adhesions, uterine fibroid, hydrosalpinx, ovarian benign tumor, and adenomyosis. The age was collected, and the change of age and the incidence of endometriosis was analyzed. Results The incidence of endometriosis in infertile female inpatients was 35.50%(95%CI:34.50%-36.49%). The incidence showed relatively stable increasing tendency after 2004 (with P〈0.01). The age had increased significantly since 1996 (with P〈0.01);the average age was (29.76±3.74) years old in 1996, and (32.85±4.49) years old in 2013 (P〈0.01). The inpatients diagnosed with endometriosis had greater age, (32.67 ± 4.06) versus (32.04 ± 4.55) years old (P〈0.01);the incidence of endometriosis differed in different age group, the older group had higher incidence (χ2=85.807, P〈0.01). Conclusions Infertile female inpatients showed increasing incidence of endometriosis in recent years. Older infertile patients maybe have higher risk of endometriosis.