中文摘要：

多发性骨髓瘤（multiple myeloma，MM）是一种恶性浆细胞单克隆增生性疾病，约占全部恶性肿瘤的1%，目前仍不能治愈，微小残留病是主要原因，因此，清除微小残留病，有可能治愈本病．在各种治疗方法中，针对多发性骨髓瘤的免疫基因疗法（Immune gene therapy或Immunogene therapy）是当今治疗的研究热点，近几年免疫基因疗法在体内外实验中取得了较好的结果，本文就免疫基因在多发性骨髓瘤治疗中的研究及应用进行综述.

英文摘要：

Multiple myeloma (MM) is a malignant plasma cell disease, accounting for about 1% of all malignant tumors, is still uncurable, minimal residual disease(MRD) is the reason, therefore,removal of minimal residual disease maybe possible to cure the disease. In a variety of treatment methods, immune gene therapy for multiple myeloma is a hot research topic in recent years, has achieved good results in vitro and in vivo experiments,in this review immune genes therapy in multiple myeloma research would be discussed.