中文摘要：

目的：观察血浆氧化型低密度脂蛋白（OX-LDL-C）和同型半胱氨酸（HCY）与冠状动脉狭窄程度间的关系，探讨其作为冠脉病变严重程度无创性预测因子的可能性。方法：将86例疑似冠心病患者根据冠脉造影结果分为冠心病组及非冠心病组，冠心病组又分为单支病变组、双支病变组和多支病变组，分析血浆OX-LDL-C、HCY与冠脉病变严重程度的关系，检测诊断冠心病的ROC曲线，并确定OX-LDL-C与HCY诊断冠心病的临界值。结果：冠心病组血浆OX-LDL-C、HCY水平均高于非冠心病组（P<0.05）；血浆OX-LDL-C、HCY水平随病变支数的增加而升高，且差异均有统计学意义（P<0.05）；OX-LDL-C临界值为527.5μg/L，HCY临界值为13.5μmol/L，其诊断冠心病有较高的敏感度及特异度。结论：血浆OX-LDL-C和HCY水平对诊断冠心病具有较高价值，可用于冠心病的临床早期危险分层，有利于及时识别高危冠心病患者，降低冠心病的病死率。

英文摘要：

Objective:To observe the relationship of oxidized low density lipoprotein (OX-LDL-C), homocysteine (HCY) in plasma and stenosis de-gree of coronary, and to investigate the possibility of regarding them as non-invasive predictors for severity of coronary lesions. Methods:According to the result of coronary angiography, 86 cases of suspected coronary heart disease patients were divided into CHD group and NCHD group, then again divided patients of CHD group into single-vessel group, double-vessel group and multi-vessel group, analyzed the relationship of OX-LDL-C, HCY in plasma and stenosis degree of coronary, tested the ROC curve for diagnosis of coronary heart disease, and determined the critical value of OX-LDL-C and HCY for diagnosis of coronary heart disease. Results:The levels of OX-LDL-C and HCY in plasma of CHD group were both higher than those of NCHD group (P<0.05);the levels of OX-LDL-C and HCY in plasma was increasing with the increasing of the lesion branches, which differences were statistically significant (P<0.05);it had a high sensitivity and specificity for diagnosis of coronary heart disease when the critical val-ue of OX-LDL-C was 527.5μg/L and HCY was 13.5μmol/L. Conclusion:The levels of OX-LDL-C and HCY in plasma have high value in diagno-sis of coronary herat disease, which can be used for early risk stratification, helpful to identify the high-risk patients with coronary heart disease time-ly, and decrease the mortality of coronary heart disease.