中文摘要：

娃儿藤生物碱因其显著的抑制肿瘤生长活性及新的抗癌作用机制而受到化学和药学研究者的广泛关注。该文对自2002年以来关于娃儿藤生物碱和基于该类生物碱设计的类似物的分子结构与抗肿瘤作用的构效关系以及该类化合物抗肿瘤作用机制的最新研究成果进行综述,并对其研发前景加以展望。

英文摘要：

Much attention has been payed to tylophora alkaloids due to their potent cytotoxic activity against a broad range of human cancer cells and a novel mechanism of anticancer action.Recent development on the relationship between structures of tylophora alkaloids（including their analogs） and their antitumor activity is reviewed.Research on their mechanism of anticancer action is also described.