中文摘要：

在肿瘤切除手术或肿瘤放射治疗之前对肿瘤引起的周围血管和神经的位移和形变的评估和预测极重要。为模拟良性肿瘤生长对周围血管的影响，用细胞自动机方法模拟肿瘤生长，根据四面体各个顶点是否属于肿瘤体的各种情况时肿瘤几何模型进行网格化、并建立有限元力学模型。对颅底局部连续切片图像重建三维几何模型，提取血管模型并按曲率的相对值自适应细化血管网格，建立薄壳力学模型。通过碰撞检测得到血管和肿瘤的接触点集并施加大小相等方向相反的外力，以模拟生长过程中肿瘤与血管相互力的作用。模拟实验表明，在肿瘤生长过程中血管和肿瘤各自发生弯曲和形变与实际情况基本一致，实验模型可以在一定程度上预测肿瘤生长情况及其对周围组织的影响。

英文摘要：

It is very important to predict displacements and deformations of the vessels and nerves near tumor before actinotheraphy or surgery. To simulate the influence to blood vessel induced by the growth of benign tumor, cellular automata was employed to simulate the tumor growth, and the tumor geometrical model was meshed according to the various cases in which some vertices belonged to tumor but the remains not in order to construct the finite model. The vascular model was extracted from the partial head model which was built from a series of picture of cranial base, and the mesh was refined with adaptive method to get the thin shell model. By collision detection method, contacted points were located and the forces were exerted on the point sets to simulate interaction. The experiment illuminate that the changes of shape and location of tumor and blood vessels conform to actual cases, and the model can predict the tumor growth status and the influence to tissues around the tumor to some degree.