中文摘要：

目的：分析NF-κB,Gadd45γ蛋白在肝细胞性肝癌中的差异表达,探讨其在肝癌尤其是HBV感染型肝癌发生发展中的意义。方法：应用免疫组化方法检测NF-κB,Gadd45γ蛋白在64例肝癌和48例癌旁组织中的表达情况,并结合HBV感染状态与临床病理资料进行分析。结果：NF-κB在感染型肝癌组织中的表达率高于癌旁组织和非感染型肝癌。Gadd45γ在感染型肝癌组织中的表达率低于癌旁组织和非感染型肝癌组织,差别具有统计学意义（P〈0.05）。NF-κB的表达与肝癌的分化程度,转移能力有关;NF-κB,Gadd45γ表达呈负相关（P〈0.05）。结论：HBV感染型肝癌组织中NF-κB的高表达,Gadd45γ的低表达并NF-κB部分介导的Gadd45γ表达下调共同参与了肿瘤的发生发展。

英文摘要：

Objective：To study the differential expression of NF-κB,Gadd45γ in hepatocellular carcinoma and validate the significance in the tumorigenesis and progression.Methods：The expression of NF-κB,Gadd45γ in 64 hepatocellular carcinoma tissues and 48 adjacent non-neoplastic tissus were detected with immunohistochemical maxvision method,and the results were anaiyzed combined with condiction of HBV infection and clinical pathologic characteristics.Results：In contrast with the expression of Gadd45γ,the positive rate of NF-κB in HBV-infected hepatocellular carcinoma tissues were higher than that in adjacent non-neoplastic tissus and non HBV-infected hepatocellular carcinoma tissues（P〈0.05）.The expression of NF-κB was correlated with differentiation of tumor and metastasis.In addition,There was a negative correlation between the expression of NF-κB and Gadd45γ（P〈0.05）.Conclusion：The high expression of NF-κB and the low expression of Gadd45γ in hepatocellular carcinoma especially in HBV-infected hepatocellular carcinoma may play a crucial role in the tumorigenesis and progression.