中文摘要：

有丝分裂激酶Aurora-A具有调节中心体分离、成熟以及纺锤体装配的功能，并且在调节细胞周期Q／M期转变以及检测点（checkpoint）方面发挥重要的作用。近年来研究证实Aurora-A过表达与中心体异常、非整倍体、细胞转化以及肿瘤发生方面存在很大程度的相关性，并通过对抑癌基因p53以及癌基因c-Myc等的调节促进肿瘤的发生。

英文摘要：

Aurora-A kinase plays an important role in centrosome separation, maturation and bipolar spindle assembly during mitotic phase. Aurora-A is also involved in the regulation of the G2/M transition and checkpoint. Overexpression of Aurora-A leads to centrosome amplification, aneuploidy as well as oncogenic transformation in cells, and correlates with tumorigenesis which can be induced by Aurora-A degradation turnout-suppressor gene p53 and upregulation oncogene c-Myc.