中文摘要：

Gadd45a，一个受p53和BRCAI调节的生长阻滞和DNA损伤基因，在抑制细胞转化和肿瘤恶性进展中扮演重要的角色．Gadd45a可以通过抑制细胞生长以及促进DNA损伤修复等间接或者直接方式维持基因组稳定性，从而抑制细胞转化和肿瘤的恶性进展．此外，Gadd45a还可通过对一些信号传导通路的调节，参与肿瘤发生发展的抑制．

英文摘要：

Gadd45a, a p53 and BRCAl-regulated growth arrest and DNA damage gene, plays important roles in suppressing cell transformation and tumor malignancy. Gadd45a maintains the genomic stability through inhibiting the cell growth and promoting the DNA repair etc, by which it suppresses the tumor development. Additionally, Gadd45a is involved in some important signaling pathway, contributing to its function in tumor suppressing.