中文摘要：

目的：研究晶状体损伤对视神经再生的促进作用，并探讨巨噬细胞所起的作用。方法：成年SD大鼠钳夹造成视神经损伤模型（NC），戳伤晶状体（IP），玻璃体内注射酵母多糖（ZI）或注射体外活化的单核／巨噬细胞（MI），动物以此分组。用Nissl染色法显示存活的视网膜节细胞（RGCs），用抗GAP-43抗体标记轴突再生RGCs，用抗ED-1抗体标记活化的单核／巨噬细胞。结果：NC＋LP组存活的RGCs比NC组明显增加，再生的RGCs及活化的单核／巨噬细胞都有明显增多的结果。NC＋ZI组与NC＋MI组也有类似结果。结论：晶状体损伤具有显著促进视神经再生的作用，其机制可能与趋化并激活巨噬细胞有关。

英文摘要：

Objective： To study the neurite-promoting activity of lens injury on retinal ganglion cells （RGCs） and to explore the role of macrophages in this neuroprotection. Methods： Optic nerve injury was induced in adult SD rats by crushing the nerve （NC）. Meanwhile, lens received intraocular penetration （LP）; zymosan （ZI） or stimulated monocytes/macrophages （MI） were injected intravitrously. Animals were divided into 4 groups randomly. The survived RGCs were labeled by cresyl fast violet; the regenerating axons and RGCs were labeled by anti- GAP-43 antibody. Monocytes/macrophages were activated by anti-ED-1 antibody. Results： The number of survived RGCs in NC＋LP group increased significantly. Increased GAP-43 expression and ED-1 positive cells were observed; similar results were obtained in NC＋ZI group and NC＋MI group. Conclusion： The findings indicate that lens injury has high neuroprotective and neurogenic activity, which may be related with the stimulation of macrophages.