中文摘要：

目的了解福州地区绝经后妇女维生素D受体基因TaqⅠ多态性的分布，探讨维生素D受体基因TaqⅠ多态性与绝经后妇女骨密度的关系。方法用双能x线骨密度仪检测592例绝经后妇女的膜椎、股骨颈、大转子和Ward’s三角骨密度，应用PCR-RFLP技术检测维生素D受体基因TaqI多态性。结果①维生素D受体基因型分布频率为TT型90．37％，tt型0．17％，Tt型9．46％。等位基因频率为T95．1％，t4．9％，基因型分布符合Hardy．Weinberg定律。②分析其基因型与骨密度的关系：TT、tt、Tt3种基因型在腰椎、股骨颈、大转子、Ward’s区4个部位骨密度差异均无显著性。结论维生素D受体基因TaqⅠ多态性与骨密度间无关联，不能作为预测福州地区绝经后妇女发生骨质疏松危险性的遗传标志。

英文摘要：

Objective To investigate the prevalence of vitamin D receptor （VDR） gene polymorphism in Fuzhou postmenopausal women and to study the relationship between Taq Ⅰ polymorphism of VDR gene with bone mineral density（BMD）. Methods BMD of lumbar spine, femoral neck, trochanter and Ward＇s triangle of 592 postmenopausal women were measured by dual energy X-ray absorptiometry. The genotype of VDR gene was determined by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）. Results （1）The distribution of VDR genotypes were TT 90.37 %, tt 0.17 %, Tt 9.46 %, respectively. The T allelic gene frequencies reached 95.1%, while t was 4.9% . The distribution followed the Hardy-Weinberg equilibrium. （2） Analysis of the relationship between the genotypes and BMD ： There is no significant difference in BMD of lumbar spine, femoral neck, troehanter and Ward＇s triangle among the three genotypes. Conclusion Taq Ⅰ gene polymorphism of VDR is not correlated to BMD, and there is no enough evidence to support genotype of VDR as a genetic marker in predicting the risk of developing osteoporosis in Fuzhou postmenopausal female.