中文摘要：

目的观察丹酚酸／丹参酮配伍对凝血酶诱导人脐静脉内皮细胞（HUVEC）细胞炎症因子P-selection、E-selection的影响。方法培养HUVEC细胞，设空白对照组、凝血酶损伤模型组、丹酚酸／丹参酮配伍50μg／I。组、丹酚酸／丹参酮配伍100／μg／I，组。采用ELISA法检测细胞上清液中P－selection、E－selection含量。结果丹酚酸／丹参酮配伍50tμg／L100μg／L均可显著降低经凝血酶诱导而升高的P－selection含量（P〈O．01），丹酚酸／丹参酮配伍100μg／L可显著降低经凝血酶诱导而升高的E－selec－tion含量（P〈O．05）。结论丹酚酸／丹参酮配伍可通过抑制炎症因子P－selection、E－selection表达而抗凝血酶诱导的HUVEC炎症损伤。

英文摘要：

Objective To observe the effect of salvianolic acid/tanshinones compatibility on thrombin induced human umbilical vein endothelial cells （HUVEC） P selection and E selection. Methods HUVEC cells were cultured and divided into blank control group,thrombin injury model group, salvianolic acid/tanshinones 50 μg/L group, salvianolic acid/tanshinones 100 μg/I, group. The contents of P selection and E selection in culture supernatants were detected by ELISA. Results Compared with thrombin injury model group, the content of P selection was decreased in salvianolic aeid/tanshinones 50 μg/L group and salvianolic acid/tanshinones 100 /μg/L group（P〈0.01）. The content of E selection was decreased in salvianolic acid/tanshinones 100 μg/L group（P〈0.05）. Conclusion The satvianolic acid/tanshinones compatibility could ameliorate thrombin induced HUVEC inflammatory injury through inhibition of the inflammatory cytokines P selection and E selection expression.