中文摘要：

为了研究硼元素对大鼠淋巴结和视网膜组织结构的影响,试验选用断乳（21d±2d）清洁级SD大鼠60只,适应性饲养1周后,随机分为对照组和试验Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ组,各组分别通过饮水添加0、40、80、160、320和640 mg/L硼,试验期60d。结果显示,与对照组相比,试验Ⅰ和Ⅱ组大鼠淋巴结皮质内淋巴小结数量增多,体积增大,淋巴细胞密集,副皮质区增厚,髓质内髓索明显增粗;视网膜组织结构发育良好,节细胞层、内核层和外核层细胞数量有所增多。试验Ⅲ组大鼠淋巴结皮质内淋巴小结减少,体积变小,副皮质区变薄,淋巴细胞排列较为疏松;视网膜组织结构出现轻微损伤,内核层变薄,节细胞层细胞数量排列疏松,数量减少。试验Ⅳ和Ⅴ组大鼠淋巴结皮质内淋巴小结体积显著减小,生发中心不明显甚至消失,淋巴细胞明显减少,副皮质区变薄,髓索变细;视网膜节细胞层变薄,数量减少,部分细胞出现空泡,内核层和外核层细胞排列疏松。说明饮水添加40～80mg/L硼对大鼠淋巴结和视网膜组织结构发育具有一定的促进作用,而添加320～640mg/L硼则对大鼠淋巴结和视网膜组织结构产生明显的损伤作用。

英文摘要：

In order to study the effect of boron on microstructure of lymph nodes and retina in rats, 60 weaned clean level SD rats （21 dq-2 d） were randomly divided into the control group and experimental I , II , HI , IV , V groups after adaptive feeding for 1 week, which were respectively added 0, 40, 80, 160, 320, 640 mg/L boron by drinking water. The experiment lasted for 60 d. The results showed that compared with the control group, the quantity and volume of lymphoid nodules were increased with intensive lymphocytes in lymph node cortex, and paracortexes and medullary cord became thick in the experi- mental I and 1I groups, the quantity of cells increased in the ganglion cell layer, inner nuclear layer and outer nuclear layer of well-developed retina. The quantity and volume of lymphoid nodules were decreased in the lymph node cortex, and paracortex- es were thinner with loose arrangement of lymphocytes in the experimental [lI group, the retina had minor injury, and the inter nuclear layer became thin, the ganglion cells decreased and loosed. The lymphoid nodules in the lymph node cortex significantly decreased, and germinal center was not obvious or even disappeared, in which the lymphocytes significantly decreased, the paracortexes and the medullary cord became thin, the ganglion cell layer was thinner, and the ganglion cells were decreased with vacuolated cytoplasm, the cells were loosely arranged in the inter nuclear layer and the outer nuclear layer. Above results indicated that addition 40 to 80 mg/L boron promoted the development of lymph node and retina in the rats to some extent, and addition 320 to 640 mg/L boron had obviously damaged effect on the structure of lymph node and retina in the rats.