中文摘要：

谷氨酸脱氢酶（GDH）存在于所有生物体中，在三羧酸循环、氨代谢调控、能量产生和信号转导中起着重要作用。关于GDH的研究报道已有很多，涉及到植物氮代谢、微生物生理、动物神经调节以及其本身的生产应用，但有关其与人类疾病间关系的文献综述尚未见报道。在对GDH基本特性进行归纳和总结的基础上，对其与高胰岛素．高血氨综合征、帕金森病，以及不同癌症间关系等方面的最新研究进展进行了综述，以期为相关研究提供参考。

英文摘要：

Glutamate dehydrogenase （GDH） exists in all living organisms and plays an important role in the Krebs cycle, ammonia metabolism regulation, energy production and cell signaling. Many researches have been carried out on GDH in recent years, including plant nitrogen metabolism, microbial physiology, animal neural regulation and its application in industrial production. However, there is still lack of comprehensive review on the relationship between this enzyme and human diseases. Therefore, this article reviewed the new development in the characteristics of GDH, and its relationship with some diseases, especially with hyperinsulinism/hyperammonemia syndrome, Parkinson＇s disease and cancers to provide useful information for relative researches in the future.