中文摘要：

在新生的疾病考察 epigenetic 规定的角色并且更好理解 Barker 是“数据在这引用了的 .Data 来源考察的成年疾病假设的胎儿的起源”的目的主要从在在与 epigenetics 和新生的疾病联系的1953年1月和2009年12月 .Study 选择文章之间的 Medline/PubMed 出版的文章被获得是有的 selected.Results 降低出生重量的很多流行病学的证据强烈与增加的风险被相关成年疾病的胎儿的起源的这现象强烈与胎儿的侮辱被联系到基因的 epigenetic 修正。在先天的混乱的 epigenetic 修正的一个潜在的角色，短暂新生的糖尿病 mellitus ( TNDM )，子宫内的生长延迟( IUGR )，并且新生儿( PPHN )的坚持的肺的高血压是在新生的疾病的这些 epigenetic 修正的角色的 studied.Conclusions 承认将对更好理解这些疾病的致病导致，并且为以后的成年疾病的改进处理和预防提供新卓见。

英文摘要：

Objective To review the role of epigenetic regulation in neonatal diseases and better understand Barker＇s ＂fetal origins of adult disease hypothesis＂.Data sources The data cited in this review were mainly obtained from the articles published in Medline/PubMed between January 1953 and December 2009.Study selection Articles associated with epigenetics and neonatal diseases were selected.Results There is a wealth of epidemiological evidence that lower birth weight is strongly correlated with an increased risk of adult diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular disease. This phenomenon of fetal origins of adult disease is strongly associated with fetal insults to epigenetic modifications of genes. A potential role of epigenetic modifications in congenital disorders, transient neonatal diabetes mellitus （TNDM）, intrauterine growth retardation （IUGR）, and persistent pulmonary hypertension of the newborn （PPHN） have been studied.Conclusions Acknowledgment of the role of these epigenetic modifications in neonatal diseases would be conducive to better understanding the pathogenesis of these diseases, and provide new insight for improved treatment and prevention of later adult diseases.