中文摘要：

研究了苯甲酰化壳聚糖（DBC）和天然生物分子氨基酸在选择性溶剂N，N-二甲苯甲酰胺（DMF）和水中的自组装行为．在超声波作用下，透明的混合溶液出现蓝白色乳光，同时紫外-可见光谱呈现透光率的突变，体系完成了自组装．自组装是通过两组分之间的氢键作用产生的．用动态光散射（DLS）和透射电镜（TEM）分别研究了自组装粒子的尺寸和形态．实验结果表明，苯甲酰化壳聚糖和氨基酸可以形成纳米尺寸或亚微米尺寸的自组装微粒，形成的微粒为球形或椭球形，微粒的尺寸为60-720nm．粒子的尺寸显著受pH值和氨基酸种类的影响，因而可以利用pH值和氨基酸的种类控制自组装粒子的尺寸．

英文摘要：

Self-assemble of two kinds of natural biodegradable substances, i. e. beazoylchitosan and amino acids in selective solvents DMF and water was studied. Under ultrasonic treatment, mixed solution which is transparent gradually presented blue-white opalescence. At the same time, uv-vis spectra presented mutation of transmittance. The.self-assemble of this system was finished. The behavior of self-assemble is induced by hydrogen bonding. The morphology and the size of the particles were characterized by dynamic light scattering （DLS） and transmission electron microscope （TEM）. The results showed that benzoylchitosan and amino acids can self-assemble to form nanoparticles or submicron particles. The shape of the particles was spheroid or sphere,the size of the particles was 60-720 nm. The size of the self-assembly particles can be influenced both by the pH of solution and the species of amino acids. Therefore,we can adjust pH and the species of amino acids to control the size of self-assemble particles.