中文摘要：

采用纳米粒度仪和TEM比较研究了尿石症患者和正常人尿液中〈1000nm的纳米微晶的Zeta电位、光强自相关函数曲线、平均粒径和粒度分布。结果表明，在相近尿PH（6．0左右）时，尿石症患者尿液中纳米微晶的Zeta电位值（平均为-3．16mV）明显大于正常人（平均为-10．1mV）。相比较正常人尿液，尿石症患者尿液中纳米微晶的散射光强存在更长时间的相关性，说明尿石症患者尿液中纳米微晶的粒径大于正常人。粒度分布检测进一步表明，正常人尿液中粒径在350nm以下的纳米微晶占大多数，而患者尿液中粒径〉600nm的纳米微晶占大多数。实验结果有助于了解正常人尿液和尿石症患者尿液的差异，为尿石症的早期检测提供线索。

英文摘要：

The Zeta potential, intensity-autoeorrelation curve, mean size and distribution ot nanocrystallites with a size less than 1000 nm in urines of lithogenie patients and healthy people were investigated by nanoparticle size analyzer and transmission electron microscope （TEM）. It indicated that the Zeta potential of nanocrystallites in lithogenie urines （with an average value of -3.62mV） was much larger than that in healthy urines （mean value -10.1mV） under the similar urine pH （about 6.0）. Comparing with healthy urines,the scattering intensity of nanocrystallites in lithogenie urines had much longer correlation. It revealed that the size of nanocrystallites in lithogenie urines was larger than that in healthy urines. Size distribution measurement further indicated that most of the nanoerystallites in healthy urines had a size of less than 350nm,while the size of most of the nano- erystallites in lithogenic urines was larger than 600nm. The experimental results in this article may help us to understand the difference between healthy urines and lithogenie urines, which could provide clues for the early diagnose of urolithiasis.