中文摘要：

目的：观察蜘蛛香环烯醚萜类成分ZXX对小鼠腹泻的治疗作用。方法：采用番泻叶致小鼠腹泻模型、应激加番泻叶致小鼠腹泻模型和利血平致小鼠腹泻模型,观察ZXX对腹泻模型小鼠排便的影响。结果：ZXX高剂量可显著延长番泻叶模型小鼠和应激加番泻叶模型小鼠的排便潜伏期;ZXX的3种剂量均可显著减缓利血平化模型小鼠的肠推进率;ZXX各剂量有增加利血平化小鼠自主活动趋势,但无统计学意义;ZXX高、中剂量组对利血平慢性给药所致体温下降均有明显拮抗作用并可明显逆转利血平化小鼠闭眼状况。结论：蜘蛛香环烯醚萜类成分ZXX具有止泻作用,提示其可能是改善腹泻型肠易激综合征的有效物质基础。

英文摘要：

Objective：To research the effect of Iridoid constituents of Valeriana jatamansi Jones ZXX on the mice model of diarrhea and gastrointestinal dysfunction.Methods：This study used mice model of diarrhea developed by feeding senna,feeding senna add stress and reserpine mice model to obverse the effect of arresting diarrhea of ZXX.Results：The high dose of ZXX could prolong the defecation incubation period of diarrhea mice model significantly in statistics.The three doses of ZXX could prolong the propulsion of intestine,in addition the high and middle doses of ZXX could be antagonistic for hypothermia,eyelid closure and increase autonomic activities.Conclusion：ZXX had an obvious effect of anti-diarrhea,which suggested ZXX could be the basic chemical constituents of effective substance to treat diarrhea irritable bowel syndrome.