中文摘要：

为了利用可食用的β-环糊精合成一种新型的可降解、对人体没有毒副作用的金属有机骨架化合物（CD-MOF）,利用溶剂热方法,采用分子自组装合成了一种新型的金属有机骨架化合物,分子式为K（C42H64O35）·11H2O.通过元素分析、IR光谱、X-射线粉末衍射和X-射线单晶衍射对其进行了结构表征.分析表明,该晶体属于单斜晶体,P21空间群,晶胞参数a=15.235（5）A,b =10.594（5）A,c=20.241（5）A,α=γ=90.000°,β=108.180°,V=3 103.8（19） （A）3.以包合率为指标,设计4因素3水平的正交试验筛选制备阿奇霉素K-CD-MOF包合物的最佳制备工艺.结果表明主客体摩尔比为1∶1、包合温度为40℃,滴加时间为20 min,包合时间为2h为最佳制备工艺,包合率最高,包合率可以达到（33.91±1.2）％.

英文摘要：

To obtain a new biodegradable, no toxic effect to human body metal-organic framework （MOF） by using the edible nature fl-cyclodextrin （β-CD） , a new CD based MOF compound, K（ C42H69O35 ）. 11H2O （K-CD- MOF）, has been synthesized and characterized by elemental anslysis, IR spectra and single crystal X-ray diffrac- tion methods. The crystal of K-CD-MOF belongs to monoclinic system with space group P21 , a = 15.235 （5） A,b = 10. 594 （5） A, c = 20. 241 （5） A, α = γ = 90. 000° ,β = 108. 180°, V = 3103.8 （ 19 ） A3. An optional condition for azithromycin （AM） was established by the orthogonal design of four factors and three levels by using the inclu- sion rate as criteria of selecting the optional condition. The result shows that the best techniques of the inclusion compound preparation are as follow ： the mol ratio of drug to K-CD-MOF was 1 ： 1 by grinding, and inclusion time was two hours and inclusion temperature was 40 ℃ With these results the inclusion rate was highest. Its average rate of inclusion was （33.91 ± 1.2）%.