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跗管扩大减压术对大鼠糖尿病性胫神经病变的作用研究
  • ISSN号:1001-2036
  • 期刊名称:《中华显微外科杂志》
  • 时间:0
  • 分类:R658[医药卫生—临床医学;医药卫生—外科学]
  • 作者机构:[1]中日友好医院神经外科,北京100029
  • 相关基金:国家自然科学基金资助项目(81173424,81373796)
中文摘要:

目的探讨周围神经减压术联合丹红注射液治疗痛性糖尿病性下肢周围神经病变的临床疗效。方法28例痛性糖尿病性下肢周围神经病患者,分为实验组与对照组,均行腓总神经、腓深神经、胫后神经主干及其分支显微减压术,术后分别应用丹红注射液和甲钴胺治疗,观察两组疗效差异。结果对照组获得50%以上和30%以上疼痛缓解率者分别占47.0%和64.7%,实验组为72.2%和94.4%;实验组腓、胫神经感觉传导速度改善5m/s以上的比例为72.2%和83.3%,优于对照组47.1%和70.6%;多伦多临床神经病变评分(TCSS)改善,实验组为(6.71±1.98)分同样优于对照组(4.93±2.50)分。结论周围神经显微减压术是治疗痛性糖尿病性周围神经病变的有效方法,术后辅以丹红注射液可获得更佳疗效。

英文摘要:

Objective The clinical efficacy of microsurgical pen'pheral nerve decompression combined Danhong injection for treatment of painful diabetic peripheral neuropathy of lower limbs is analyzed. Methods A total of 28 patients with painful diabetic peripheral neuropathy were enrolled in this study. Both the common peroneal nerve, deep peroneal nerve, posterior tibial nerve and its branches were perfo~ the nerve decompression. And then Danhong was administered in the experimental group, while Methylcobalamin was used in the control group. Results In the control group, 47.0% of the patients got 〉50% pain relief, and 64.7% of patients got 〉30% pain relief. However, the rate was 72.2% and 94. 4% in the experimental group; more than 5 m/s sensory conduction velocity improvement of tibial nerve and the peroneal nerve were 72.2% and 83.3% in the experimental group, compared to 47. 1% and 70. 6% in the control group ; Toronto clinical scoring system (TCSS) scores of the experimental group (6. 71 ± 1.98) were also better than that of the control group (4. 93 ± 2. 50). Condmion Microsurgical peripheral nerve decompression is effective for the treatment of painful diabetic peripheral neuropathy, and a better curative effect can be achieved if combined with post-operative Danhong injection.

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期刊信息
  • 《中华显微外科杂志》
  • 北大核心期刊(2011版)
  • 主管单位:中国科学技术协会
  • 主办单位:中华医学会
  • 主编:
  • 地址:广州市中山二路74号
  • 邮编:510080
  • 邮箱:zhxwwk@mail.sysu.edu.cn
  • 电话:020-87330683
  • 国际标准刊号:ISSN:1001-2036
  • 国内统一刊号:ISSN:44-1206/R
  • 邮发代号:46-107
  • 获奖情况:
  • 国内外数据库收录:
  • 日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:19416