目的探讨周围神经减压术联合丹红注射液治疗痛性糖尿病性下肢周围神经病变的临床疗效。方法28例痛性糖尿病性下肢周围神经病患者,分为实验组与对照组,均行腓总神经、腓深神经、胫后神经主干及其分支显微减压术,术后分别应用丹红注射液和甲钴胺治疗,观察两组疗效差异。结果对照组获得50%以上和30%以上疼痛缓解率者分别占47.0%和64.7%,实验组为72.2%和94.4%;实验组腓、胫神经感觉传导速度改善5m/s以上的比例为72.2%和83.3%,优于对照组47.1%和70.6%;多伦多临床神经病变评分(TCSS)改善,实验组为(6.71±1.98)分同样优于对照组(4.93±2.50)分。结论周围神经显微减压术是治疗痛性糖尿病性周围神经病变的有效方法,术后辅以丹红注射液可获得更佳疗效。
Objective The clinical efficacy of microsurgical pen'pheral nerve decompression combined Danhong injection for treatment of painful diabetic peripheral neuropathy of lower limbs is analyzed. Methods A total of 28 patients with painful diabetic peripheral neuropathy were enrolled in this study. Both the common peroneal nerve, deep peroneal nerve, posterior tibial nerve and its branches were perfo~ the nerve decompression. And then Danhong was administered in the experimental group, while Methylcobalamin was used in the control group. Results In the control group, 47.0% of the patients got 〉50% pain relief, and 64.7% of patients got 〉30% pain relief. However, the rate was 72.2% and 94. 4% in the experimental group; more than 5 m/s sensory conduction velocity improvement of tibial nerve and the peroneal nerve were 72.2% and 83.3% in the experimental group, compared to 47. 1% and 70. 6% in the control group ; Toronto clinical scoring system (TCSS) scores of the experimental group (6. 71 ± 1.98) were also better than that of the control group (4. 93 ± 2. 50). Condmion Microsurgical peripheral nerve decompression is effective for the treatment of painful diabetic peripheral neuropathy, and a better curative effect can be achieved if combined with post-operative Danhong injection.