中文摘要：

目的：探讨黏附复合体相关蛋白E-cadherin、β-catenin及p120在人类卵巢癌组织中的表达及其与患者临床病理特征及预后的关系。方法：采用免疫组织化学染色法检测281例卵巢癌患者肿瘤组织中Ecadherin、β-catenin及p120的表达水平,分析其与临床病理特征之间的关系,比较其在卵巢癌原发灶与转移灶之间的差异。结合患者随访资料,利用Kaplan-Meier法绘制生存曲线,Log-rank法分析E-cadherin、β-catenin或p120的表达水平与卵巢癌患者预后的关系,COX回归模型分析卵巢癌患者预后的独立预测因素。结果：β-catenin在卵巢癌原发灶与转移灶间表达水平具有统计学差异（P=0.018）,卵巢癌组织中p120的表达水平与患者FIGO分期（P=0.043）、组织学类型（P〈0.001）、肿瘤分级（P〈0.001）有关,Spearman法分析证实E-cadherin与β-catenin（P=0.005）、β-catenin与p120（P〈0.001）、E-cadherin与p120（P〈0.001）具有相关性,卵巢癌组织中β-catenin（P=0.008）及p120（P=0.006）低表达的患者较高表达者总生存期缩短,多因素分析发现FIGO分期、β-catenin或p120表达水平是卵巢癌患者总生存期的独立预测因素。结论：鉴于黏附复合体在卵巢癌发生、浸润及转移中均发挥了重要作用,综合评估其相关蛋白E-cadherin、β-catenin及p120的表达水平,有助于判断卵巢癌的生物学行为及预测患者的预后。

英文摘要：

Objective ：To investigate the expressions of E -cadherin, v -catenin and p120, which belong to the related elements of cadherin catenin complex, and analyze the correlations between the levels of their expressions and clinieopathological features or prognosis in human epithelial ovarian carcinoma. Methods ： The expressions of E - cad- herin, β - catenin and p120 in 281 eases of ovarian carcinoma tissues were determined by immunohistochemical meth- od. The correlations between their expressions and clinicopathological features and the difference between their expres- sions in primary and metastatic lesions were analyzed, respectively. In combination with follow - up data, survival curves were calculated using the Kaplan - Meier method and the survival rates were analyzed by the log - rank test. COX regression model was used to examine the independent predictive factors in the patients with ovarian carcino- ma. Results：There was statistically significance in the expression level of β - catenin between primary lesions and metastatic lesions （P = 0. 018 ）. The expression level of p120 in ovarian carcinoma was correlated to FIGO stage （P = O. 043 ）, histological type （ P 〈 O. 001 ） and tumor grade （ P 〈 O. OO1 ）. Furthermore, there were significant relations between the expressions of E - cadherin and 13 - catenin （P =0. 005） ,β - catenin and p120 （P 〈0.001 ） ,E - cad- herin and p120 （P 〈0. 001 ） by spearman analysis. The patients with lower expression level of β - catenin （P = O. 008） or p120 （P = 0. 006） in ovarian carcinoma tissues had shorter overall survival duration than those of higher expression level. The multiple factor analysis revealed that FIGO stage and the expressions level of β- catenin or p120 were independent predictive factors in overall survival duration. Conclusion： Given a critical role of cadherin catenin complex in ovarian tumorgenesis,invasion and metastasis, a comprehensive evaluation to the expression level of its related proteins （