中文摘要：

目的：探讨N-cadherin在人类卵巢癌组织中的表达及其临床．病理意义。方法：采用免疫组织化学染色法检测281例卵巢癌患者肿瘤组织中N-cadherin的表达，并分析其与患者临床病理特征之间的关系。结果：N-cadherin在卵巢癌原发灶中的表达显著低于配对的转移灶（P=0．018）；卵巢癌组织中N-cadherin的表达与患者FIGO分期（P=O．034）、组织学类型（P〈0．001）、肿瘤分级（P=0．004）均显著相关。结论：N-cadherin高表达更多见于进展期（FIGOⅡ-Ⅳ）0t7巢癌、高级别浆液性癌及高级别卵巢癌，可能与卵巢癌细胞的侵袭及迁移能力呈正相关．对判断卵巢癌的生物举行为具有重要的参孝价值．

英文摘要：

Objective： To explore the expression of N-cadherin and its correlations with the clinicopathological features of human ovarian carcinoma. Methods： The expression of N-cadherin in 281 cases of ovarian carcinoma tissues were determined by immunohistochemical method. The correlations of N-cadherin expression with the clinicopathological features of human ovarian carcinoma were analyzed. Results： There was higher expression of N-cadherin in the metastatic lesions than its paired primary lesions （P = 0.018）. The expression level of N-cadherin in ovarian carcinoma was correlated with the FIGO stage （P = 0.034）, histological type （P 〈 0.001） and tumor grade （P = 0.004）. Conclusions： High expression of N-cadherin might positively correlate with the invasion and migration ability of ovarian carcinoma cells, which was more common in the the advanced （FIGO II-IV） ovarian carcinoma, high-grade serous carcinoma, and high grade ovarian carcinoma. N-cadherin might be useful in estimating the biological behavior of human ovarian carcinoma.