中文摘要：

目的：研究Beagle犬静脉滴注银杏内酯B注射液后的药代动力学特征。方法：采用LC-MS法测定银杏内酯B经时血药浓度,采用DAS 2.0实用药代动力学程序计算其药代动力学参数。结果：Beagle犬单次静脉滴注低、中、高三个剂量银杏内酯B注射液,银杏内酯B主要药代动力学参数：Tmax分别为0.444、1、1 h,Cmax均值分别为0.764、3.024、11.013 mg/L,AUC0-t均值分别为1.007、3.644、16.646 mg.h/L。结论：各剂量组血药浓度试验数据经拟和优度分析,药物消除符合二室模型,AUC0-t、AUC0-∞、Cmax随剂量的增加而增加,均呈剂量依赖性的正比关系,体内动力学过程符合线性动力学特征。

英文摘要：

Objective：To study the phaImacokinetics of ginkgolide B injection in Beagle dogs. Methods：Determined the serum concentration of ginkgolide B by LC-MS and calculated its parameter of pharmacokinetics via DAS 2.0 software. Results ： After intrave-nous drips of 0. 62,2. 07 and 10. 35 mg/kg ginkgolide B, parameters of pharmacokineties of ginkgolide B were as follows ： Tmax were 0. 444,1 , 1 h;Cmax were 0. 764,3. 024,11.013 mg/L;AUC0, were 1. 007,3. 644,16. 646 mg · h/Lo Conclusion ： Ginkgolide B has two compartment model in Beagle dogs.