中文摘要：

应用常规电生理学技术,研究小鼠听皮层对中脑下丘神经元方位敏感性的下行调制。实验记录了198个下丘神经元的听反应,这些神经元的最佳方位角大多数(84.8%)位于听空间对侧20°～50°范围内。根据神经元的方位敏感曲线特征,将这些神经元分为方位选择型、半场型、多峰型和全向型四种调谐模式。电刺激听皮层对绝大多数下丘神经元方位角的范围产生易化(42.0%)或抑制(45.0%)效应,并使59.3%的神经元的最佳方位角发生了转移。结果提示,小鼠下丘神经元具有明显的方位敏感性,听皮层对下丘神经元听觉方位信息处理具有下行调制作用。此研究结果为深入研究中枢听觉信息处理的离皮质调控机制提供了重要实验资料。

英文摘要：

Conventional electrophysiological technique was used to determine the corticofugal modulation of the directional sensitivity of mouse inferior colliculus. Among 198 inferior collicular neurons, the best azimuth of most of neurons (84.8%) ranged from 20° to 50°. According to the directional sensitivity curve, these neurons were divided into Azimuth-selective neuron, Hemi-field neuron, Multi-peak neuron and Non-selective neurons. After cortical electrical stimulation, Azimuth range of most of inferior collicu...