中文摘要：

目的：比较HBV相关性肝细胞癌患者的肝癌组织与癌旁组织中miR-375的表达。方法：以西京医院进行肝癌切除术治疗的HBs Ag阳性的25例患者为研究对象,收集肝癌组织、癌旁组织及术前外周血标本,并采集相关临床信息。采用反转录和实时荧光定量PCR的方法检测组织中miR-375的表达水平。结果：本研究共收集的25例肝癌患者HBs Ag均为阳性,在肝癌组织中miR-375的表达水平为2.51×10-3±3.61×10^-3,显著低于在癌旁组织中的表达水平（15.23×10^-3±20.85×10^-3;t=3.12,P〈0.05）。结论：miR-375在HBV相关性肝细胞癌肝癌组织中表达显著下调。

英文摘要：

Objective： To investigate the miR-375 expression profiles in hepatocellular carcinoma（HCC） tissues and adjacent non-tumor tissues. Methods： Quantitative real-time polymerase chain reaction（q RT-PCR） was applied to examine the expression of miR-375 in 25 HCC from patients who were diagnosed and operated, in comparion with the corresponding adjacent non-tumor tissues.Based on the medical records, the relevant information was extracted. Results： There were 25 HCC patients in the study. HBs Ag of all patients were positive. The expression of miR-375 in HCC tissues was 2.51 ×10^-3±3.61×10^-3, the expression of miR-375 in adjacent non-tumor tissues was 15.23 ×10^-3±20.85×10^-3. The expression of miR-375 in HCC tissues significantly lower than that in adjacent non-tumor tissues（P〈0.05）. Conclusion： miR-375 expression was significantly decreased in tumor tissues of HCC patients.