中文摘要：

以2-氯-4-硝基苯酚和2-氰基-4-硝基苯胺为起始原料,经7步反应完成了EGFR酪氨酸激酶抑制剂Varlitinib的全合成,总收率18.2%,其结构经1H NMR和13C NMR确证。

英文摘要：

Varlitinib was synthesized in total yield of 18. 2% by a seven-step reaction,using 2-chloro-4-nitrophenol and 2-amino-4-nitrobenzonitrile as the starting materials. The structure was confirmed by1 H NMR and13 C NMR.