中文摘要：

树突状细胞（DCs）是体内功能最强的抗原呈递细胞，其表面的DCs特异性细胞间黏附分子-3结合非整合素因子（DC-specific ICAM-3 grabbing nonintegrin，DC-SIGN）一方面可介导DCs对病原体的结合和抗原呈递，有利于宿主免疫应答；另一方面也可被胞内寄生病原体利用，协助其感染宿主T细胞，并通过干扰DCs成熟来影响其抗原呈递能力，抑制宿主免疫功能。目前研究认为，DC-SIGN基因多态性及表达差异可能会影响宿主对病原体的易感性。

英文摘要：

Dendritic cells（DCs） are professional antigen-presenting cells. The binding of pathogens to DC-specific intercellular adhesion molecule 3 （ICAM-3） grabbing nonintegrin（DC-SIGN） can lead to not only phagoeytosis of DCs to pathogens, but also decreased proliferative activity of DCs to active allogenic T cell by inter-fering with maturity of DCs and inhibited human immune function. Polymorphism and differential expression of DC-SIGN on DCs may have important impact on the susceptibility of human to infectious diseases.