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基于静息态fMRI低频振幅的首发抑郁症与功能脑区关联研究

ISSN号：1004-9037
期刊名称：数据采集与处理
时间：2015.9.15
页码：940-947
分类：R749.4[医药卫生—神经病学与精神病学;医药卫生—临床医学]
作者机构：[1]大连理工大学电子信息与电气工程学部,大连116024, [2]大连医科大学附属第二医院,大连116027
相关基金：国家自然科学基金（81241059,61172108）资助项目; 国家科技支撑计划（2012BAJ18B06）资助项目
相关项目：基于Renyi熵和相关熵的Alpha稳定分布信号处理新方法及应用研究

关键词：功能磁共振, 静息态, 抑郁症, 低频振幅, functional magnetic resonance imaging, resting-state, depression, amplitude of low-frequency fluctuation

中文摘要：

利用功能磁共振成像（Functional magnetic resonance imaging,fMRI）技术,研究静息态下首发抑郁症患者脑功能的改变。采用Siemens3.0T磁共振仪对5名首发抑郁症患者和1名性别年龄相仿的正常对照志愿者进行静息态fMRI采集,采用低频振幅（Amplitude of low-frequency fluctuation,ALFF）的方法分析数据,进行双样本t检验后分析静息态脑功能的差异。结果发现,抑郁症组大脑左侧小脑6区、左侧颞下回、双侧尾状核、右侧舌回、左侧眶部额上回、右侧中央沟盖、右侧前扣带和旁扣带脑回、右侧额中回、右侧岛盖部额下回、右侧补充运动区、左侧顶上回、右侧中央后回、右侧背外侧额上回ALFF降低。首发抑郁症患者大脑的额叶、颞叶、扣带回及尾状核等位置存在功能异常,这些区域的异常与情绪、认知、记忆等领域有关,与抑郁症息息相关。

英文摘要：

To investigate the discrepancies in brain function of first-episode depressed patients,five firstepisode depressed patients and one healthy volunteer of the same age undergo resting-state functional magnetic resonance imaging（fMRI）scans by Siemens 3.0Tand collecting data are anylized by the amplitude of low-frequency fluctuation（ALFF）.Then,the ALFF results are possessed by two-sample t-test.The result shows the ALFF value of the depressed group are decreased in the particular areas,including the left cerebellar lobe,the left superior temporal gyrus,the bilateral caudate nucleus,the right lingual gyrus,the left superior frontal gyrus,the right rolandic operculum,the right anterior cingulate gyri,the right middle frontal gyrus,the right inferior frontal gyrus,the right supplementary motor area,the left superior parietal gyrus,and the right postcentral gyrus.The research result suggests that the first-episode depressed patients have functional discrepancies in the frontal lobe,the temporal lobe,the cingulate gyrus and the caudate nucleus.These areas are directly correlated with emotion,cognition and memory.Abnormalities in these areas are closely bound up with depression.

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