中文摘要：

在超声快速制取组织细胞病理切片的过程中。发现激励信号对切片制取效果有明显的影响．为了掌握超声激励信号对组织细胞的影响规律，达到快速制取病理切片的最佳状态，从气泡空化模型入手，通过改变激励信号频率、声压、气泡初始半径和液体黏滞系数等参量，研究了声孔效应中气泡动力学激励机制．数值计算表明：空化泡振动随激励声压增强而升高。随液体黏滞系数增强而减弱；一定频率范围内空化泡振动能保持在膨胀、收缩和振荡的稳定空化状态，存在空化泡稳态振动的最佳激励频率；一定初始半径能保证空化泡产生稳定的振动，存在空化泡稳态振动幅度最大的初始半径，实际操作中，在频率、声压、初始半径和黏滞系数综合作用的若干空化阈内，声孔效应使超声快速法制取细胞组织切片获得最佳效果．

英文摘要：

During the process of quickly producing pathologic sections of the living tissues with ultrasonic sonoporation, it has been found that the exciting ultrasonic signal has an evident effect on the pathologic section. For the sake of understanding the effect and obtaining the best state of quickly producing pathologic section, the bubble dynamics in ultrasonic sonoporation is investigated by constructing a model of cavitated bubbles and altering the parameters, such as the ultrasonic signal frequency, acoustic pressure, bubbles＇ original radius and viscosity of the fluid. Numerical simulations indicate that radial vibration of cavitating bubble can keep on a steady process of expanding, shrinking, and vibrating in a given rang of frequencies, and one can find out the best original radius for obtaining the maximal cavitation. There exist a best cavitation regions which are determined by the parameters, i.e., the ultrasonic signal frequency, acoustic pressure, bubbles＇ original radius and viscosity of body fluid.