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醒脑开窍针刺法调节脑梗死患者血流动力学的临床研究
  • 分类:R246.6[医药卫生—针灸推拿学;医药卫生—中医临床基础;医药卫生—中医学]
  • 作者机构:天津中医药大学第一附属医院针灸研究所,300193
  • 相关基金:国家自然科学基金项目(81001550); 天津市应用基础及前沿技术研究计划项目(11JCYBJC13100)
作者: 李晶
中文摘要:

目的观察醒脑开窍针刺法调节脑梗死患者血流动力学参数的干预效应及规律。方法选择2015年1至10月天津中医大学第一附属医院住院患者30例接受醒脑开窍针刺法治疗4周。采用随机区组设计双因素方差分析治疗前、治疗2周后和治疗4周后3个时间点中医证候疗效评价、美国国立卫生研究院卒中量表(NIHSS)及巴氏指数(BI)的差异;采用配对t检验比较针刺治疗前、治疗4周后脑梗死患者患侧大脑中动脉(MCA)、颈内动脉(ICA)终末段和基底动脉(BA)的收缩期血流速度(Vs)、舒张期血流速度(Vd)、平均血流速度(Vm)、脉冲指数(PI)及阻力指数(RI)的差异。结果 (1)醒脑开窍针刺法治疗脑梗死恢复期患者,治疗2周后在中医症状积分为(9.67±3.76)分,优于治疗前(15.10±4.98)分,且差异有统计学意义(q=16.61,P〈0.01);治疗2周后NIHSS评分和BI分别为[(6.50±2.40)、(50.00±17.61)分,较治疗前[(7.53±2.43)、(48.13±14.26)分]有改善,并且差异均有统计学意义(q=16.97、18.49,P均〈0.01)。治疗4周后,中医症状积分、NIHSS评分和BI分别为(6.77±3.05)、(5.50±1.74)、(69.13±14.26)分,均优于治疗前和治疗后2周,且差异均有统计学意义(q=14.07、14.81、15.55,P均〈0.01;q=12.16、17.34、26.56,P均〈0.01)。(2)大脑主要动脉的Vs和RI在治疗前和治疗4周后差异均无统计学意义;与治疗前相比[(36.41±3.92)、(25.28±5.35)、(57.7±7.94)、(35.87±8.36)cm/s],针刺治疗后MCA和BA的Vd和Vm均加快[(44.07±2.92,28.12±2.92,63.17±4.51,40.37±4.54)cm/s],且差异均有统计学意义(t=-10.043,P〈0.01;t=-3.271,P〈0.05;t=-4.097,P〈0.01;t=-3.807,P〈0.01),而ICA的Vd和Vm治疗前和治疗4周后差异无统计学意义(P〉0.05)。MCA的PI治疗后(0.80±0.02)较治疗前(0.96±0.13)下降,且差异有统计学意义(t=6.95,P〈0.01)。BA和ICA的PI治?

英文摘要:

Objective To observe the intervention effects and changes on hemodynamic parameters in cerebral infarction patients treated with(consciousness-restoring resuscitation) acupuncture.Methods Thirty patients selected in the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine(TCM)from January 2015 to October were treated with consciousness-restoring resuscitation acupuncture for four weeks.The efficacy was observed before and after treatment.The two-way analysis of variance of randomized block design was used to compare changes of the U.S.National Institutes of Health Stroke Scale(NIHSS)and Barthel index(BI) were evaluated in patients before and after treatment.The paired t-test was used to compare changes of hemodynamic parameters middle cerebral artery(MCA),the internal segment of carotid artery(ICA) and the terminal segment of the basilar artery,systolic flow velocity(Vs),diastolic flow velocity(Vd),mean velocity(Vm),pulse index(PI) and resistance index(RI).Results(1) The Chinese medicine symptom score was significantly changed from(15.10±4.98) points to(9.67±3.76) points in cerebral infarction patients after treatment with consciousness-restoring resuscitation acupuncture for two weeks(q=16.61,P0.05).The NIHSS scores and BI were significantly changed from[(7.53±2.43),(48.13±14.26)]points to[(6.50±2.40),(50.00±17.61)]points in cerebral infarction patients after treatment with consciousness-restoring resuscitation acupuncture for two weeks(q=16.97 and 18.49,P0.05).After 4-week treatment,The Chinese medicine symptom score,NIHSS score and BI were[(6.77±3.05),(5.50±1.74) and(69.13±14.26)]points,which were much better than those before treatment and two weeks after treatment,the difference was statistically significant(q=14.07,14.81,15.55,P0.01;q= 12.16,17.34,26.56,P0.01).The results showed that consciousness-restoring resuscitation acupuncture had good therapeutic effect on stroke recovery

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