中文摘要：

利用三种合成的封端水性聚氨酯PU（WDDA）来改性胶原（col）,结果表明,在碱性水溶液中,WDDA能有效交联胶原的氨基,经TDI—WDDA、IPDI-WDDA、HMDI-WDDA改性后的胶原TOC含量分别提高了23.1%,30.1%、46.2%。TG/DTG、DSC分析结果显示,交联改性后的胶原热稳定性显著提高,特别是HMDI—WDDA交联后的胶原具有最高的热变性温度（93.2℃）。FTIR的研究显示,尽管交联改性可以增加胶原三股螺旋结构的稳定性,但交联程度越高胶原分子的天然构象受到的影响越大,螺旋结构的完整性越差。胶原吸水率测试以及体外胶原酶水解实验表明,WDDA交联可以显著降低胶原的吸水率同时增强其酶解稳定性。

英文摘要：

Three kinds of blocked waterborne polyurethane synthetized in-house were used to modify collagen.The results showed that WDDA can react with amino groups in collagen, and the TOC content of modifided collagen were increased by 23.1% for TDI-WDDA-eol, by 30.1% for IPDI-WDDA-col, and by 46.2% for HMDI-WDDA-col. TG/DTG and DSC analysis results demonstrated the thermal stability of crosslinked collagen increased significantly. Especially, collagen crosslinked with HMDI-WDDA has the highest thermal denaturation （9.3.2 ℃ ）.b-FIR analysis revealed that although the crosslinking can increase the stability of collagen triple helix, the higher the degree of crosslinking, the larger impact on natural conformation of collagen and the worse integrity of triple helix there has been. Water absorption and in vitro hydrolysis experiments showed that crosslinking of collagen significantly reduced the water absorption rate and inhibited the enzymolysis reaction.