中文摘要：

晚期糖基化终产物受体（the receptor for advanced glycation end products，RAGE）属于免疫球蛋白家族。在中枢神经系统，RAGE主要在神经元、小胶质细胞及血管内皮细胞上表达。阿尔采末病（Alzheimer’s disease，AD）人脑中RAGE的表达可被β淀粉样蛋白（β—amyloid protein，Aβ）上调，上调的RAGE进一步促进了AD的发展。神经元、小胶质细胞和血管内皮细胞膜上RAGE和Aβ结合，引起神经元毒性、持久性的炎症反应、血管功能紊乱。对RAGE—Aβ作用机制的深入理解，可为AD的临床治疗提供理论基础。

英文摘要：

Receptor for advanced glycation end products （RAGE） is a member of the immunoglobulin supeffamily. In central nervous system, RAGE is mainly expressed by neurons, microglia, and cerebral endothelial cells. In Alzheimer＇s disease （AD） brain, levels of RAGE are significantly increased from the positive feedback mechanisms driven by excess amounts of β- amyloid protein （Aβ）. The interaction of RAGE with Aβ in neurons, microglia, and cerebral endothelial cells induces the perturbation of neuronal functions, amplification of microglia inflammatory responses, and vascular dysfunction. Further understanding the molecular mechanisms associating RAGE-Aβ interaction provides us the opportunity to develop the therapeutic approaches for the devastating disease.