脓毒症相关免疫抑制是脓毒症患者发生院内获得性感染或死亡的重要原因。脓毒症相关免疫抑制在感染早期即可能发生,主要表现为免疫细胞功能下降,抑制性细胞、凋亡比例增加。及时对脓毒症相关免疫抑制的发生进行监测,有助于全面评价患者病情,指导免疫调节治疗,从而改善患者的预后。本文就脓毒症相关免疫抑制监测的研究进展进行综述。
Sepsis-induced immunosuppression is held responsible for higher morbidity and morality of opportunistic bacteria infection in septic patients. Sepsis-induced immunosuppression may exist in early stage of sepsis,with impaired immune function including increasing immunosuppressive cells and cell apoptosis. It is important to monitor immunosuppression during sepsis to guide adjunctive immune therapies. In this review, we will focus on the recent findings in monitoring sepsis-induced immunosuppression.