中文摘要：

目的：研究猕猴桃根多糖（APPS）脂质体对D-半乳糖胺所致小鼠急性肝损伤的保护作用。方法：采用D-半乳糖胺所致小鼠急性肝损伤模型，以联苯双酯为对照药，以小鼠血清中ALT、AST等为指标，评价APPS脂质体的抗急性肝损伤作用。结果：APPS脂质体口服液高剂量（200mg／kg）对D-半乳糖胺所致小鼠急性肝损伤药效作用结果显著（P〈0．05或P％0．01）。低剂量（50mg／kg）对各肝损伤模型的治疗则无显著性意义（P〉0．05）。结论：APPS脂质体口服液对小鼠急性肝损伤有较好的保护作用。

英文摘要：

AIM： To study the preventive and therapeutic effects of APPS Liposome on mice acute liver injury induced by D-galactosamine. METHODS： D-galactosamine was given to establish the acute liver damaged mouse models. ALT, AST in mice blood were examined as in- dexes to study on the antiacute liver injury effect of APPS Polyphase liposome oral liquid, with bifendate as a control drug. RESULTS ： High dosage of APPS Polyphase liposome （200 mg/ kg） have a significant effect on the acute liverdamaged mice models（P〈0.05 or P〈0.01）, low dosage（50 mg/kg）has no significant effect on the models （P 〉0.05）. CONCLUSION： The results indicated that preventive and therapeutic effects of APPS Polyphase Liposome on mice acute liver injury are significant.