中文摘要：

观察心梗诱导的大鼠肥厚心肌中三磷酸腺苷（ATP）敏感性钾离子通道（KATP）的表达，并探讨其影响因素．将雄性大鼠随机分为5组，分别是假手术组，手术组，普萘洛尔组，氯苄基四氢小檗碱组及内皮素受体拮抗剂组．手术组及药物组的大鼠结扎冠脉左前降支，术后饲养10d，药物组于术后第6天开始给药，共给药5d，由反转录-多聚酶链式反应（RT-PCR）方法确定Kn即通道的mRNA表达．实验结果表明，心梗诱导的大鼠肥大心肌中的Kn即通道的mRNA表达明显上调，经药物干预后有不同程度的降低．心梗诱导的大鼠肥厚心肌中的KATP通道的mRNA的表达上调，其表达上调除与口受体有关外，Ca^2＋离子可能参与对KATP通道表达的影响．

英文摘要：

Aim to observe the expression of ATP-sensitive potassium （KATe） channel in infarct produced myocardial remodeling and the factors were studied. Methods： male sprague-dawley rats randomly divided into five groups, sham-operated, operated and three treatment groups including propranolol, p-chlorobenzyltetrahydroberberine and endothelin receptor antagonist. Myocardial infarction was induced by the left anterior descending coronary artery was ligated with a silk suture. Sham-operated controls were treated likewise, except that the suture around the coronary artery was not closed. From 5 d the treatment groups were administered drugs after coronary artery ligation. All animals were killed on 10 d after ligation. The expression of mRNA for KAXP channels was studied in rat hypertrophic myocardium using reverse transcription-polymeric chain reaction （RT-PCR）. Results： The expression of KATe channel in infarct produced myocardial remodeling displayed up-regulted. After treatment the expression of KATe channel shown down-regulated in different degree. Conclusion： The expression of KATe channel in infarct produced myocardial remodeling displayed up-regulated. The factors involved in Ca^2＋ except β receptor, the effect of Ca^2＋ on the expression of KATe in infarct produced myocardial need study more.