中文摘要：

目的 在大鼠杏仁核电点燃癫痫模型中研究丘脑底核高频深部电刺激对点燃的抑制作用及其对Glu、GABA浓度的影响.方法 建立大鼠杏仁核电刺激点燃模型,观察丘脑底核高频深部电刺激对点燃发作的抑制作用,应用高效液相色谱（HPLC）测定大鼠脑组织中Glu、GABA的浓度.结果 对丘脑底核高频深部电刺激（130 Hz,0.2 ms,5 V）能够有效抑制大鼠杏仁核电点燃（P＜0.05）;并可以降低纹状体内Glu浓度,升高纹状体内GABA浓度（P＜0.05）.结论 丘脑底核高频深部脑电刺激能有效抑制大鼠杏仁核电点燃,其作用机制可能与改变Glu、GABA浓度平衡有关.

英文摘要：

Objective To investigate the inhibition of high frequency deep brain stimulation-subthalamie nucleus on amygdale kindling in rat, and to explore the change of neurotransmitter in brain striatum. Methods The effects of high frequency deep brain stimulation on kindling were examined by the establishment of amygdale kinkling model in rats. The concentration of Glu and GABA was detected by HPLC. Results High frequency stimulation （130Hz,0.2ms,5V）inhibited effectively the seizure severity in amygdale kindling （P 〈 0.05） and lowered the concentration of Glu （P 〈 0.05）, and increased the concentration of GABA （P 〈 0. 05）. Conclusion High frequency deep brain stimulation-subthalamic nucleus can significantly suppress amygdala kindling in rats, with possible mechanisms of the change of balance of Glu and GABA.