中文摘要：

目的：应用正电子发射断层扫描（positron emission tomography，PET）／计算机断层成像（computed tomography，CT）技术研究棕色脂肪组织（brown adipose tissue，BAT）活动情况对荷瘤小鼠肿瘤组织摄取18F-氟-2-脱氧葡萄糖（18F-fluoro一2一deoxyglucose，18F-FDG）的影响。方法：建立人肺癌NCI-H1299小鼠移植瘤模型，随后采用人工控制实验条件的方法调节小鼠BAT的活动；实验分为2组：抑制组通过禁食、麻醉和加热处理抑制BAT的活动，激发组则通过食物干预和冷刺激激发BAT的活动。对2组小鼠进行micro-PET／CT成像检测，比较BAT不同活动状态下小鼠肿瘤摄取18F-FDG的情况，并计算标准摄取值（standard uptake value，SUV）。结果：BAT激发组小鼠的肿瘤在PET／CT图像中几乎是不可见的，其摄取协F-FDG的SUV值为0.15±0.06，显著低于BAT抑制组的0.58±0.20（P〈0.05）。结论：BAT活动的增加会显著降低肿瘤对18F-FDG的摄取，从而影响肿瘤的成像效果。

英文摘要：

Objective： To evaluate the influence of BAT （brown adipose tissue） activity on 18F-FDG （18F-fluoro-2-deoxyglucose） uptake in tumors in cancer-bearing mice by using PET/CT （positron emission tomography/computed tomography） imaging. Methods： The model of mice bearing NCI-H1299 human non-small cell lung cancer was established. The activity of BAT in mice was adjusted through regulating the experimental conditions. Two groups were designed in this study, including BAT-activation group （the activity of BAT in mice was stimulated by cold exposure and food diet during the period of 18F-FDG uptake） and BAT-inhibition group （the activity of BAT in mice was inhibited by fasting, anesthesia and heating）. The mice were scanned with micro-PET/CT and the uptake of 18F-FDG in tumors in the two groups was analyzed and compared. The SUV （standard uptake value） was calculated. Results： The tumor in BAT-activation group was nearly invisible on PET image and its 18F-FDG uptake value （SUV 0.15±0.06） was significantly lower than that in the BAT-inhibition group （SUV 0.58±0.20） （P 〈 0.05）. Conclusion： The enhancement of BAT activity will significantly decrease the uptake of 18F-FDG in tumors and influence the imaclincl of the tumors.