中文摘要：

目的探讨外周血白细胞（WBC）计数水平与回汉民族2型糖尿病（T2DM）之间的关系。方法采用病例-对照研究,于2011年10月至2012年10月在宁夏医科大学附属医院和吴忠市人民医院内分泌科住院患者及在门诊健康体检者中,按照纳入和排除标准,以性别、民族和年龄相差不超过3岁进行病例和对照的匹配,最终确定351例T2DM患者作为病例组和655例健康人群作为对照组,进行问卷调查（包括一般情况、生活方式、疾病及用药史、家族史）、体格检查[包括身高、体重、腰围（WC）、收缩压（SBP）和舒张压（DBP）,并根据身高和体重计算体质指数（BMI）]以及实验室检测[包括甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、血尿酸（UA）、门冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）等血液生化指标]。结果糖尿病组平均年龄（50.28±8.32）岁,男性194例（55.27%）,女性157例（44.73%）;对照组平均年龄（50.17±7.14）岁,男性337人（51.45%）,女性318人（48.55%）;两组间平均年龄、性别构成比的差异均无统计学意义。糖尿病组外周血WBC水平[（6.66±1.61）×10^9/L]明显高于对照组[（6.11±1.49）×10^9/L],差异有显著性（t=-5.430,P〈0.01）,回族外周血WBC平均水平[（6.459±1.45）×10^9/L]与汉族[（6.169±1.63）×10^9/L]比较,差异有统计学意义（P〈0.05）;糖尿病组白细胞异常率为2.6%,对照组为0.8%,糖尿病组显著高于对照组（χ2=4.168,P=0.041）;调整年龄、性别、民族、TG、TC、HDL、LDL、ALT、AST、血糖等因素后,外周血WBC异常人群糖尿病的发病风险是外周血WBC正常人群的4.072倍;调整年龄、性别、患病与否、TG、TC、HDL、LDL、ALT、AST、血糖等因素后,回族人群外周血WBC增高的风险是汉族人群的1.582倍。结论 WBC计数水平与2型糖尿病密切相关,并随其水平升高,这种关联逐渐增强,说明W

英文摘要：

Objective To analyze the relationship between WBC count levels and type 2 diabetes mellitus in Hui and Han nationality of Ningxia. Methods Using the method of case-control study, people of regional organizations and institutions aged 20 - 60 who received medical health checkup and endocrine patients in General Hospital of Ningxia Medical College and WuZhong city People＇s Hospital from October 2011 to October 2012 were enrolled in the study. According to the inclusion and exclusion criteria of T2DM patients and control groups, with gender, ethnic and age are not more than 3 years old cases and controls of matching,the T2DM group （case group） of 351 cases and non- T2DM group （control group） of 655 cases were determined. These subjects underwent questionnaire investigation, understand first, like the situation, the way of life, disease and medication history, family history. Physical examination： including height, weight, waist circumference （WC）, systolic blood pressure （SBP） and diastolic blood pressure （DBP） , and according to the height and weight to calculate body mass index （ BMI）, and laboratory tests, triglyceride （TG）, total cholesterol （TC）, high-density lipoprotein （HDL-C） , low density lipoprotein （ LDL-C ） , blood uric acid （ UA ） , nmda aminotransferase （AST）, alanine aminotransferase （ALT）, blood biochemical indexes. Results Diabetes group of average age （50. 28 ± 8. 32）, 194 patients with male, （55.27%）, 157 patients with female （44. 73%） and control group in average age （50. 17 ± 7.14） , including 337 men （51.45%） and 318 women （48.55%）. Average age, gender, the proportion between the two groups had no statistical significance of difference. The white blood cell value of T2DM group（6.66 ×10^9 ± 1.61 ×10^9/L）was higher than that of non-T2DM group （6.11 ×10^9 ± 1.49 ×10^9/L） , there was a significant difference （t = - 5. 430, P 〈 0.01 ） ; Comparing the mean value of white blood cell of Hui（6.459 ×1