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Hepatic artery bridging lessens temporary ischemic injury to bile canaliculi
  • ISSN号:1007-9327
  • 期刊名称:《世界胃肠病学杂志:英文版》
  • 时间:0
  • 分类:R[医药卫生]
  • 相关基金:Supported by National Natural Science Foundation of China,No.81170454
中文摘要:

AIM We undertook this meta-analysis to investigatethe relationship between revascularization and outcomesafter liver transplantation.METHODS: A literature search was performed usingMeSH and key words. The quality of the included studieswas assessed using the Jadad Score and the Newcastle-Ottawa Scale. Heterogeneity was evaluated by the χ 2and I 2 tests. The risk of publication bias was assessedusing a funnel plot and Egger's test, and the risk of biaswas assessed using a domain-based assessment tool.A sensitivity analysis was conducted by reanalyzing thedata using different statistical approaches.RESULTS: Six studies with a total of 467 patients wereincluded. Ischemic-type biliary lesions were significantlyreduced in the simultaneous revascularization groupcompared with the sequential revascularization group(OR = 4.97, 95%CI: 2.45-10.07; P 〈 0.00001),and intensive care unit (ICU) days were decreased(MD = 2.00, 95%CI: 0.55-3.45; P = 0.007) in thesimultaneous revascularization group. Althoughwarm ischemia time was prolonged in simultaneousrevascularization group (MD = -25.84, 95%CI:-29.28-22.40; P 〈 0.00001), there were no significantdifferences in other outcomes between sequential andsimultaneous revascularization groups. Assessment ofthe risk of bias showed that the methods of randomsequence generation and blinding might have been asource of bias. The sensitivity analysis strengthenedthe reliability of the results of this meta-analysis.CONCLUSION: The results of this study indicate thatsimultaneous revascularization in liver transplantationmay reduce the incidence of ischemic-type biliarylesions and length of stay of patients in the ICU.

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  • 《世界胃肠病学杂志:英文版》
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  • 主办单位:百世登出版集团有限公司
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  • 地址:太原双塔西街77号
  • 邮编:100023
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  • 电话:0351-4078656
  • 国际标准刊号:ISSN:1007-9327
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  • 被引量:12408